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Updated: May 3, 2026

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
Decisional procalcitonin thresholds are not adapted to elderly patients admitted to the emergency room
Camille Chenevier-Gobeaux1, Eloise Trabattoni, Yaelle Elfassy
1Groupe hospitalier Cochin-Broca-Hôtel Dieu, APHP, Department of Biochemistry, Paris, France. camille.gobeaux@cch.aphp.fr
Context:
Diagnosis of sepsis in elderly is challenging.
Objectives:
We investigated whether procalcitonin concentrations in elderly differed from values for the general population.
Methods:
Procalcitonin measurement was assessed prospectively in 307 apyretic patients ≥75 years visiting the emergency department.
Results:
Median age was 86 years [IQR81-90] and 222 (72%) were female. Procalcitonin concentration was 0.057 µg/L [0.040-0.092]; 99th percentile was 0.661 µg/L. Patients with procalcitonin concentrations above decisional thresholds had lower glomerular filtration rate and higher C-reactive protein concentrations.
Conclusions:
Baseline procalcitonin levels are increased in elderly. Elevated values are common and associated to low-grade inflammation and lower eGFR.
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