Related Experiment Video
Updated: May 22, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Persistent hypereosinophilia with Wells syndrome
1Department of Dermatology, Solihull Hospital, Heart of England NHS Foundation Trust, Birmingham, UK. jbpowell@doctors.org.uk
Abstract:
Since Wells and Smith first described cases of eosinophilic cellulitis (Wells syndrome; WS) in 1979, it has been noted that some but not all patients with WS present with eosinophilia. In the face of idiopathic persistent eosinophilia patients will also then fall within the hypereosinophilic syndrome (HES), which represents a multifarious spectrum of disorders of varying severity, causes and outcomes. In this article we propose that patients who present within the HES spectrum with cutaneous findings of WS and with no extracutaneous disease be classified as having 'persistent hypereosinophilia with Wells syndrome' (PHEWS).
More Related Videos
Related Concept Videos
Nephrotic Syndrome I : Introduction
Asthma I: Introduction
Hyperosmolar Hyperglycemic State
Allergic Reactions
Cushing Syndrome II: Pathophysiology
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

