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Related Concept Videos

The DNA Helix01:16

The DNA Helix

Overview
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Chromatin Packaging01:32

Chromatin Packaging

Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...

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Related Experiment Video

Updated: May 22, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Two dimensions and two States in DNA nanotechnology.

N C Seeman1, F Liu, C Mao

  • 1a Department of Chemistry , New York University , New York , NY , 10003.

Journal of Biomolecular Structure & Dynamics
|May 22, 2012
PubMed
Summary

DNA nanotechnology utilizes rigid DNA double crossover (DX) molecules to build 2D crystalline arrays and nanomechanical devices. These structures enable programmable interactions and tunable features for advanced molecular engineering.

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Last Updated: May 22, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

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Published on: April 12, 2019

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Published on: August 15, 2018

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

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Published on: May 8, 2015

Area of Science:

  • DNA nanotechnology
  • Materials science
  • Nanotechnology

Background:

  • DNA nanotechnology aims to construct periodic matter and nanomechanical devices.
  • Key requirements for crystalline components include programmable interactions, predictable structures, and rigidity.
  • Sticky-ended DNA association provides specific interactions and B-DNA formation, but individual branches are too flexible.

Purpose of the Study:

  • To develop rigid DNA components for tiling planes and creating 2D crystalline arrays.
  • To engineer nanomechanical devices using the rigidity of DNA motifs.
  • To explore the potential of DNA structures for programmable interactions and tunable features.

Main Methods:

  • Utilized antiparallel DNA double crossover (DX) molecules for plane tiling.
  • Incorporated DNA hairpins as topographic labels on 2D crystalline arrays.
  • Constructed nanomechanical devices using DX molecules linked by a B-Z transition DNA segment.

Main Results:

  • Demonstrated the formation of rigid 2D crystalline arrays using DX molecules.
  • Showcased tunable cavities within arrays by altering parallelogram components.
  • Developed a nanomechanical device exhibiting significant movement (up to 60Å) during the B-Z DNA transition.

Conclusions:

  • Rigid DNA structures like DX molecules are suitable for creating 2D crystalline arrays and nanomechanical devices.
  • DNA hairpins can serve as modifiable topographic labels for these arrays.
  • The B-Z transition in DNA provides a mechanism for responsive nanomechanical systems.