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Oxidised LDL/LDL-cholesterol ratio and coronary artery calcification in haemodialysis patients

Y Asamiya1, A Yajima, Y Tsuruta

  • 1Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1, Kawada-chou, Shinjuku-ku, Tokyo 162-8666, Japan. yukari-asamiya@citrus.ocn.ne.jp

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|May 22, 2012
PubMed

Insights

The MDA-LDL/LDL-c ratio is elevated in hemodialysis patients and independently predicts coronary artery calcification (CAC). This ratio may serve as a crucial biomarker for cardiovascular risk in this population.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biochemistry

Background:

  • Serum malondialdehyde-modified low-density lipoprotein (MDA-LDL) and its ratio to LDL-cholesterol (LDL-c) are established risk factors for atherosclerosis and cardiovascular disease (CVD).
  • Limited data exists on MDA-LDL and the MDA-LDL/LDL-c ratio in patients undergoing hemodialysis (HD), particularly concerning their association with coronary artery calcification (CAC).

Purpose of the Study:

  • To investigate serum MDA-LDL levels and MDA-LDL/LDL-c ratios in HD patients.
  • To determine the association between these markers and CAC in HD patients.

Main Methods:

  • A cross-sectional study included 57 HD patients and 26 control subjects.
  • Serum MDA-LDL concentrations and MDA-LDL/LDL-c ratios were measured.
  • CAC scores were assessed in HD patients, and associations with clinical and laboratory data were analyzed using multivariate logistic regression.

Main Results:

  • HD patients exhibited significantly higher MDA-LDL/LDL-c ratios compared to controls (P < 0.001).
  • Serum MDA-LDL levels did not differ significantly between groups.
  • CAC score positively correlated with both serum MDA-LDL level (P = 0.048) and MDA-LDL/LDL-c ratio (P = 0.006).
  • MDA-LDL/LDL-c ratio and HD duration were independently associated with CAC score (P = 0.003 and P = 0.007, respectively).

Conclusions:

  • The MDA-LDL/LDL-c ratio is significantly elevated in HD patients compared to non-HD subjects.
  • This ratio is independently associated with CAC score in HD patients.
  • The MDA-LDL/LDL-c ratio may represent a significant risk factor for CAC development in hemodialysis patients.
Abstract

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