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Related Experiment Video

Updated: May 22, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

A population approach to precision medicine.

Muin J Khoury¹, Marta L Gwinn, Russell E Glasgow

¹Office of Public Health Genomics, CDC, Atlanta, GA 30333, USA. muk1@cdc.gov

American Journal of Preventive Medicine

|May 22, 2012

Summary

Integrating a population perspective into predictive, preventive, personalized, and participatory medicine (P4 medicine) is crucial. This approach enhances wellness and optimizes health outcomes by considering both individual and population-level interventions.

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Area of Science:

Integrative Medicine
Public Health Sciences
Systems Biology

Background:

P4 medicine aims to enhance wellness over disease treatment using systems biology and IT.
P4 medicine comprises predictive, preventive, personalized, and participatory components.

Purpose of the Study:

To propose the integration of a "fifth P" – the population perspective – into P4 medicine.
To outline how a population perspective enhances each component of P4 medicine.
To emphasize the role of population sciences in validating P4 medicine.

Main Methods:

Conceptual framework integrating population perspective into P4 medicine components.
Application of public health principles to P4 medicine.
Highlighting the necessity of population sciences (epidemiology, behavioral science, health economics, etc.).

Main Results:

A population perspective enriches predictive medicine with an ecologic health model.
Population screening principles can be applied to preventive medicine.
Evidence-based practice is key for personalizing medicine.
Participatory medicine aligns with public health core functions (assessment, policy, assurance).

Conclusions:

The integration of a population perspective is essential for realizing the full potential of P4 medicine.
Population sciences are vital for demonstrating the value and impact of P4 medicine.
Balanced strategies incorporating both population and individual interventions are optimal for maximizing health benefits and minimizing costs.