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Updated: May 22, 2026

Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice
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Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo

Rosanne Varkevisser1, Sofieke C Wijers, Marcel A G van der Heyden

  • 1Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Yalelaan 50, Utrecht, The Netherlands.

Heart Rhythm
|May 22, 2012
PubMed

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The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
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Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
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