Related Experiment Video
Updated: May 22, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
Published on: July 17, 2019
Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study
Emily Y Chu1, Karolyn A Wanat, Christopher J Miller
1Department of Dermatology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. emily.chu@uphs.upenn.edu
Selective BRAF inhibitors like vemurafenib and dabrafenib can cause skin issues, including squamous cell carcinomas and benign growths. Early recognition and biopsy of new skin lesions are crucial during treatment.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Vemurafenib, a BRAF inhibitor, treats BRAF V600E-mutated melanomas.
- It shares side effects with other RAF inhibitors, such as squamous cell carcinomas and keratoacanthomas.
Observation:
- This study details cutaneous adverse effects of vemurafenib and dabrafenib in 14 patients.
- Evaluated clinical and histologic features of skin side effects.
Findings:
- Malignant and benign growths observed, including squamous cell carcinomas and verrucous keratoses.
- Acantholytic dyskeratosis noted in warty dyskeratomas and Darier- or Grover-like rashes.
- Other effects included palmoplantar hyperkeratosis and nevi changes, with onset as early as 1 week.
Implications:
- Selective BRAF inhibitors are linked to various skin growths, necessitating vigilance.
- Awareness of potential adverse effects and a low threshold for biopsy are recommended for patients on these therapies.
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11:02The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
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08:18Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
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