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Elevated serum β₂-GPI-Lp(a) complexes levels in children with nephrotic syndrome

Chunni Zhang1, Yang Luo, Zhongwei Huang

  • 1Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, 210002 Nanjing, P. R. China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 22, 2012
PubMed

Insights

Elevated beta-2 glycoprotein I-lipoprotein(a) complexes are a significant risk factor in pediatric nephrotic syndrome. Enhanced lipoprotein(a) oxidation contributes to their formation, suggesting a potential new biomarker.

Area of Science:

  • Immunology
  • Nephrology
  • Cardiovascular Research

Background:

  • Beta-2 glycoprotein I (β₂-GPI) complexes with lipoprotein(a) [β₂-GPI-Lp(a)] are found in circulation and elevated in autoimmune diseases.
  • These complexes may play a role in pediatric idiopathic nephrotic syndrome (NS).

Purpose of the Study:

  • To investigate β₂-GPI-Lp(a) concentrations in children with NS.
  • To explore the relationship between β₂-GPI-Lp(a), serum lipids, oxidized lipoprotein, and renal function in pediatric NS.
  • To assess the potential of β₂-GPI-Lp(a) as a biomarker for pediatric NS.

Main Methods:

  • Serum concentrations of β₂-GPI-Lp(a) and oxidized Lp(a) [ox-Lp(a)] were measured using ELISAs in 80 NS children and 82 controls.
  • Serum lipids and kidney function parameters were determined.
  • Multivariate logistic regression analyzed the association between β₂-GPI-Lp(a) and NS.

Main Results:

  • Children with NS showed significantly higher β₂-GPI-Lp(a) (0.95 U/ml vs 0.28 U/ml) and ox-Lp(a) (14.55 mg/l vs 2.60 mg/l) levels compared to controls (P<0.0001 for both).
  • β₂-GPI-Lp(a) positively correlated with ox-Lp(a) (r=0.246, P=0.028) and ox-Lp(a) with Lp(a) (r=0.301, P=0.007) in NS children.
  • Multivariate analysis revealed a strong independent association between NS and β₂-GPI-Lp(a) (OR=13.694, P<0.0001).

Conclusions:

  • Elevated β₂-GPI-Lp(a) is an independent risk factor for pediatric NS.
  • Increased Lp(a) oxidation contributes to the formation of β₂-GPI-Lp(a) complexes in pediatric NS.
Abstract

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