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Updated: May 22, 2026

Use of Bisection to Reduce Mitochondrial DNA in the Bovine Oocyte
Published on: July 6, 2022
Unique mitochondrial DNA in highly inbred feral cattle
Gavin Hudson1, Ian Wilson, Brendan I A Payne
1Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Abstract:
The Chillingham herd of wild Northumbrian cattle remains viable despite over 300 years of in-breeding and a near-homozygous nuclear genome. Here we report the complete mitochondrial DNA sequence using ultra-deep next generation sequencing. Random population sampling of ~10% of the extant herd identified a single mtDNA haplotype harbouring a unique bovine variant present in all other higher mammals (m.11789C/Y421H) which may contribute to their survival.
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