Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The epigenetic archaeology of human-dog companionship.

Epigenetics·2026
Same author

Societal allostatic load under chronic threat: defensive dominance and collective efficacy (Iran as a case example).

Frontiers in behavioral neuroscience·2026
Same author

Environmental epigenetics: new horizons in redefining biological and health outcomes.

Environment international·2026
Same author

Sex-dependent biobehavioural responses to transgenerational maternal stress: evidence of stress resilience and vulnerability in the F3 generation.

Environmental epigenetics·2025
Same author

The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.

Neuroprotection (Chichester, England)·2025
Same author

Psychological and physiological differences related to supportive living situations amongst individuals with physical disabilities.

Scientific reports·2025
Same journal

Opportunities and challenges for the application of single-cell RNA sequencing and spatial transcriptomics in ischemic stroke.

Experimental neurology·2026
Same journal

Behavioral and functional characterization of early-stage Parkinson's disease models reveals attentional deficits and circuit-level connectivity alterations.

Experimental neurology·2026
Same journal

Neuropathological and functional impact of astrocyte-derived extracellular vesicles in an aged model of Alzheimer's disease.

Experimental neurology·2026
Same journal

PI3K/Akt pathway in ischemic stroke: A central regulator of neuronal survival and repair.

Experimental neurology·2026
Same journal

Hepatokines and stellakines in liver and neurological diseases: The liver-brain axis.

Experimental neurology·2026
Same journal

Structural dynamics of α-Synuclein: Multi-scale imaging insights into pathological progression across Synucleinopathies.

Experimental neurology·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Concurrent silent strokes impair motor function by limiting behavioral compensation.

Jamshid Faraji1, Kristyn Kurio, Gerlinde A Metz

  • 1Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4. jamshid.faraji@uleth.ca

Experimental Neurology
|May 22, 2012
PubMed
Summary
This summary is machine-generated.

Multiple silent strokes, even small ones, can lead to permanent motor deficits by overwhelming the brain's ability to compensate. This highlights the cumulative impact of unnoticed brain injuries.

More Related Videos

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition
07:33

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Published on: August 23, 2022

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
05:28

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Related Experiment Videos

Last Updated: May 22, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition
07:33

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Published on: August 23, 2022

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
05:28

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Area of Science:

  • Neuroscience
  • Neurology
  • Stroke Research

Background:

  • Silent strokes are frequent and can cause lasting tissue damage without apparent symptoms.
  • These unnoticed events may increase the risk of future, more severe strokes.
  • The cumulative effect of multiple silent strokes on motor function remains poorly understood.

Purpose of the Study:

  • To investigate if multiple silent strokes targeting the motor system cumulatively impair brain compensatory capacity.
  • To determine if combined lesions in the sensorimotor cortex (SMC) and dorsolateral striatum (DLS) lead to permanent functional deficits.
  • To explore the role of cortical and subcortical motor system cooperation in motor compensation strategies.

Main Methods:

  • Adult male rats underwent focal ischemia to create single lesions in the SMC or DLS, or multiple lesions affecting both areas.
  • Skilled reaching and skilled walking tasks were used to quantitatively and qualitatively assess motor compensation and recovery.
  • Behavioral assessments tracked changes in reaching accuracy and forelimb placement during locomotion.

Main Results:

  • Single lesions in either the SMC or DLS did not result in observable behavioral deficits.
  • The combination of focal ischemic lesions in both the SMC and DLS significantly perturbed skilled reaching accuracy.
  • Multiple lesions also disrupted forelimb placement during the ladder rung walking task, indicating motor deficits.

Conclusions:

  • Multiple focal infarcts, akin to silent strokes, can gradually erode the motor system's plasticity, leading to permanent deficits.
  • These findings suggest that the cumulative impact of seemingly minor, unnoticed strokes can be significant.
  • The study supports the cooperative role of cortical and subcortical motor systems in developing compensatory movement strategies after injury.