Related Experiment Video
Updated: May 22, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with
Monika Buraczynska1, Wojciech Zaluska, Iwona Baranowicz-Gaszczyk
1Laboratory for DNA Analysis and Molecular Diagnostics, Department of Nephrology, Medical University of Lublin, Lublin, Poland. monika.buraczynska@am.lublin.pl
Insights
The ICAM-1 K469E gene polymorphism, specifically the T allele, is linked to cardiovascular disease (CVD) risk in end-stage renal disease (ESRD) patients. This finding highlights a potential genetic marker for CVD susceptibility in this population.
Area of Science:
- Genetics and Cardiovascular Medicine
- Renal Disease Pathophysiology
Background:
- Intercellular Adhesion Molecule-1 (ICAM-1) is crucial in endothelial cell-leukocyte interactions and atherosclerosis pathogenesis.
- A significant ICAM-1 gene polymorphism, K469E, has functional implications.
- Cardiovascular Disease (CVD) is a major concern in end-stage renal disease (ESRD) patients.
Purpose of the Study:
- To investigate the association between the ICAM-1 K469E polymorphism and CVD risk in ESRD patients.
- To determine if this genetic variation influences susceptibility to cardiovascular events in individuals with kidney disease.
Main Methods:
- Genotyping of 1016 ESRD patients and 824 healthy controls using PCR and allele-specific oligonucleotide techniques.
- Statistical analysis including odds ratios (OR) and confidence intervals (CI) to assess allele and genotype frequencies.
- Multivariate regression analysis to identify independent risk factors for CVD.
Main Results:
- The T allele of the ICAM-1 K469E polymorphism was significantly more frequent in ESRD patients with CVD compared to those without CVD and healthy controls.
- The TT genotype showed a markedly higher prevalence in CVD-positive ESRD patients.
- Carrier status of the T allele was identified as an independent risk factor for CVD susceptibility in ESRD patients.
Conclusions:
- The ICAM-1 K469E polymorphism, particularly the T allele, is associated with an increased risk of CVD in ESRD patients.
- This genetic variation may serve as a predictive marker for cardiovascular complications in individuals with end-stage renal disease.
Abstract:
The intercellular adhesion molecule-1 (ICAM-1) mediates interaction of activated endothelial cells with leukocytes. It plays an important role in the pathogenesis of atherosclerosis. A functionally important polymorphism of the ICAM-1 gene, K469E, has been described. We investigated whether this polymorphism influences the risk of CVD in end-stage renal disease (ESRD) patients. The groups of 1016 ESRD patients and 824 healthy individuals were genotyped by PCR and allele specific oligonucleotide technique. The T allele of the K469E polymorphism was significantly more frequent in ESRD CVD+ patients than CVD- and controls (OR 2.26, 95% CI 1.87-2.72 and 1.82, 95% CI 1.55-2.11, respectively). The TT genotype was also more frequent in CVD+ patients (OR 9.90, 95% CI 6.17-15.88 vs. CVD- subgroup). When patients were stratified according to clinical outcome of CVD, there was a tendency towards higher frequencies of the T allele and TT genotype in patients with myocardial infarction (OR for T allele 1, 57, 95% CI 1.12-2.18 vs. patients without MI). In the multivariate regression analysis the carrier status of T allele of K469E was an independent risk factor of susceptibility to CVD. Our data suggest that the ICAM-1 K469E polymorphism is associated with CVD in ESRD patients.
