A novel mechanism for eukaryotic gene expression. The involvement of DNA tertiary structure in estrogen receptor recognition of its target nucleotide sequence

The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.

Cancer research·2005

Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.

The EMBO journal·2001

Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function.

The Journal of biological chemistry·2000

Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation.

Biochemistry·1999

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

The Journal of biological chemistry·1999

The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain.

The Journal of biological chemistry·1998

Artesunate targets STAT3 to alleviate Hodgkin's lymphoma via JAK-STAT/PD-L1 axis.

Biochemical pharmacology·2026

Biochemistry of protozoan Metacaspases: Structure, processing, and inhibition.

Biochemical pharmacology·2026

Targeting coagulation factor XI/XIa for anticoagulation therapy: from mechanism to drug development.

Biochemical pharmacology·2026

Thymoquinone exerts anti-inflammatory effects in multiple disease models by regulating immune-inflammatory homeostasis.

Biochemical pharmacology·2026

HSP27, cell stress, and hormesis: From mammals to humanized yeast models.

Biochemical pharmacology·2026

ZYX knockdown alleviates chemotherapy resistance in epithelial ovarian cancer.

Biochemical pharmacology·2026

Modulatory effects of MC‑100093 on astrocytic glutamate transporters and attenuation of relapse-like ethanol drinking behavior in alcohol‑preferring rats.

Journal of psychopharmacology (Oxford, England)·2026

Adenosine refines the balance of spermatogonial proliferation and differentiation.

bioRxiv : the preprint server for biology·2026

Overexpressing FLP Recombinase Can Cause Synaptic Trafficking Defects in C. elegans.

bioRxiv : the preprint server for biology·2026

Comparative Hippocampal and Serum Metabolomics Reveals Dose-related Metabolic Alterations Consistent with TDMQ20 Intervention in a Cu-Aβ₄₂-induced Mouse Model.

Molecular neurobiology·2026

Dual-Electrode Catalytic Engineering for Sustainable C─C Bond Construction via Paired Electrochemical α-Alkylation of Nitriles.

Angewandte Chemie (International ed. in English)·2026

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self-Sensitizing Cuproptosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Related Experiment Videos

A novel mechanism for eukaryotic gene expression. The involvement of DNA tertiary structure in estrogen receptor

Related Concept Videos

The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.

Rsk2 allosterically activates estrogen receptor alpha by docking to the hormone-binding domain.

Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function.

Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation.

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family.

The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain.

Artesunate targets STAT3 to alleviate Hodgkin's lymphoma via JAK-STAT/PD-L1 axis.

Biochemistry of protozoan Metacaspases: Structure, processing, and inhibition.

Targeting coagulation factor XI/XIa for anticoagulation therapy: from mechanism to drug development.

Thymoquinone exerts anti-inflammatory effects in multiple disease models by regulating immune-inflammatory homeostasis.

HSP27, cell stress, and hormesis: From mammals to humanized yeast models.

ZYX knockdown alleviates chemotherapy resistance in epithelial ovarian cancer.

Modulatory effects of MC‑100093 on astrocytic glutamate transporters and attenuation of relapse-like ethanol drinking behavior in alcohol‑preferring rats.

Adenosine refines the balance of spermatogonial proliferation and differentiation.

Overexpressing FLP Recombinase Can Cause Synaptic Trafficking Defects in C. elegans.

Comparative Hippocampal and Serum Metabolomics Reveals Dose-related Metabolic Alterations Consistent with TDMQ20 Intervention in a Cu-Aβ₄₂-induced Mouse Model.

Dual-Electrode Catalytic Engineering for Sustainable C─C Bond Construction via Paired Electrochemical α-Alkylation of Nitriles.

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self-Sensitizing Cuproptosis.

Related Experiment Videos

A novel mechanism for eukaryotic gene expression. The involvement of DNA tertiary structure in estrogen receptor...

Related Concept Videos

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A novel mechanism for eukaryotic gene expression. The involvement of DNA tertiary structure in estrogen receptor