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Pyretic action of low doses of gamma-hydroxybutyrate in rats
E E Kaufman1, L J Porrino, T Nelson
1Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
Biochemical Pharmacology
|December 15, 1990
Abstract:
gamma-Hydroxybutyrate (GHB) has been found to have a biphasic effect on body temperature with increased body temperature after low doses (5-10 mg/kg) and decreased body temperature after high doses (300-500 mg/kg). Brain levels of GHB between 30 and 60 min post-injection of GHB were not altered by the low doses (5-10 mg/kg), although a dose of 200 mg/kg produced a large increase in the brain concentration.