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Published on: March 1, 2018
NTproBNP concentrations in healthy children.
G Koerbin1, W P Abhayaratna, J M Potter
1ACT Pathology, Canberra, Australia. gus.koerbin@act.gov.au
N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in healthy children aged 8 to 12 years were assessed. NT-proBNP concentrations progressively decline with age in this pediatric group.
Area of Science:
- Pediatric cardiology
- Biomarker research
- Clinical diagnostics
Background:
- Limited reference intervals exist for BNP and NT-proBNP in pediatric populations.
- The Lifestyle of Our Kids (LOOK) study enrolled 854 healthy children.
Purpose of the Study:
- To prospectively assess NT-proBNP levels in healthy school-aged children.
- To establish age- and gender-specific reference intervals for NT-proBNP.
Main Methods:
- NT-proBNP analysis was conducted on 854 healthy children aged 8.1, 10.1, and 11.9 years.
- Data were stratified by age and gender, calculating median, range, and 2.5th/97.5th percentiles.
Main Results:
- No significant gender differences in NT-proBNP levels were observed at any age.
- Significant age-related differences were noted, particularly between younger and older children.
Conclusions:
- NT-proBNP concentrations progressively decline in healthy children between ages 8 and 12 years.
- This study's findings of lower 97.5th percentile NT-proBNP concentrations suggest stricter health criteria for participants.
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