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Related Experiment Videos

Classically conditioned ethanol stimulus control of a motor behavior.

P B Silverman1

  • 1Department of Psychiatry-MSI, University of Texas Medical School, Houston 77030.

Alcohol (Fayetteville, N.Y.)
|November 1, 1990
PubMed
Summary

Ethanol can be conditioned to induce rotation in rats, mimicking dopamine agonist effects. This suggests ethanol can acquire stimulus control over motor behavior through associative learning.

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology

Background:

  • Unilateral 6-hydroxydopamine lesions of the substantia nigra in rats cause motor asymmetry, leading to rotation in response to dopamine agonists.
  • Ethanol alone does not typically induce rotation in these lesioned rats.

Purpose of the Study:

  • To investigate if ethanol can acquire the ability to elicit rotation in lesioned rats through associative conditioning with a dopamine agonist.
  • To determine if ethanol can serve as a conditioned stimulus for apomorphine-induced rotation.

Main Methods:

  • Rats with unilateral substantia nigra lesions received paired administrations of ethanol and apomorphine.
  • Following conditioning, the effects of ethanol administration alone were assessed.
  • Control groups received unpaired or saline administrations.

Main Results:

  • Simultaneous administration of apomorphine and ethanol induced rapid contralateral rotation.
  • After conditioning, ethanol administration alone elicited apomorphine-like rotation.
  • Control animals showed no conditioned rotation, confirming ethanol's role.

Conclusions:

  • Ethanol can acquire stimulus control over motor behavior in lesioned rats through classical conditioning with apomorphine.
  • This study demonstrates associative learning of motor responses to ethanol in a neurochemical model of Parkinsonism.

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