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Absent ductus venosus--outcomes and implications from a tertiary centre
Joseph T Thomas1, Scott Petersen, Robert Cincotta
1Centre for Maternal Fetal Medicine, Mater Health Services, Brisbane, Queensland, Australia. joseph.thomas@mater.org.au
Prenatal Diagnosis
|May 22, 2012
Summary
Isolated absent ductus venosus (ADV) in fetuses shows a favorable outcome, with 100% survival regardless of umbilical venous drainage. Associated abnormalities significantly impact overall fetal survival rates.
Area of Science:
- Perinatology
- Fetal Medicine
- Congenital Abnormalities
Background:
- Absent ductus venosus (ADV) is a rare fetal anomaly with variable reported outcomes.
- Prognosis for ADV historically depended on associated fetal abnormalities and umbilical venous drainage patterns.
Purpose of the Study:
- To analyze the associations and outcomes of absent ductus venosus.
- To determine the prognostic significance of isolated ADV versus ADV with associated abnormalities.
Main Methods:
- Retrospective audit of 22 local cases (2004-2008) and prospective data collection (2008 onwards).
- Inclusion of 67 cases of isolated ADV from English literature for combined analysis.
- Total analysis of 89 cases (22 local + 67 literature).
Main Results:
- Eight cases of isolated ADV in the local cohort had live births with no adverse outcomes.
- In the combined cohort of 89 cases, 19 cases of isolated ADV demonstrated 100% survival.
- Survival for isolated ADV was independent of umbilical venous drainage, contrasting previous reports. Overall survival was 57%, decreasing to 45% with associated fetal abnormalities.
Conclusions:
- Isolated absent ductus venosus is associated with a favorable fetal outcome.
- Umbilical venous drainage patterns do not influence the prognosis of isolated ADV.
- Associated fetal abnormalities remain a critical factor in the overall survival of fetuses with ADV.
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