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Published on: September 20, 2019
A rare case of hyperammonemia complication of high-protein parenteral nutrition
Unnikrishnan Pillai1, Roopkiranjot Kahlon, James Sondheimer
1Wayne State University, Ste-908, John R Rd, Detroit, MI 48201, USA. unnikrishnanpk@yahoo.com
Abstract:
Hyperammonemia is a metabolic derangement that can be potentially fatal. Primary hyperammonemia due to urea cycle enzyme deficiency is usually discovered in neonates but rarely can present in adulthood. Late-onset manifestations of urea cycle disorders can go unnoticed, until they become life threatening. The authors report a 28-year-old man who developed hyperammonemia in the hospital following parenteral nutrition (PN), leading to cerebral edema, which was fatal despite resolution of the hyperammonemia with cessation of PN and the use of continuous renal replacement therapy.
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