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Related Experiment Video

Updated: May 22, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

Dioxins: diagnostic and prognostic challenges arising from complex mechanisms.

Noel M Rysavy1, Kristina Maaetoft-Udsen, Helen Turner

  • 1Laboratory of Immunology and Signal Transduction, Chaminade University, Honolulu, HI 96822, USA.

Journal of Applied Toxicology : JAT
|May 22, 2012
PubMed
Summary

Dioxins are widespread environmental toxins. Understanding their subtle, long-term health effects, including impacts on cancer and diabetes, requires advanced tools like genomics and epigenetics.

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Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

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Area of Science:

  • Environmental Science
  • Toxicology
  • Human Health

Background:

  • Dioxins are pervasive environmental pollutants resulting from industrialization.
  • Their full physiological harm and cellular mechanisms remain poorly understood.
  • Chronic exposure may have subtle, generational effects on complex diseases like cancer and diabetes.

Purpose of the Study:

  • To review dioxin exposure paradigms and documented physiological effects.
  • To discuss novel insights into dioxin ligands and their cellular mechanisms.
  • To highlight the need for genomics and epigenetics in understanding dioxin toxicity.

Main Methods:

  • Review of existing animal and human studies on dioxin exposure.
  • Analysis of emerging research on endogenous and exogenous dioxin ligands.

Related Experiment Videos

Last Updated: May 22, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

  • Discussion of cellular and organ-level effects of dioxins.

    • Main Results:

    • Dioxin exposure paradigms and physiological effects are summarized.
    • Mechanisms of dioxin action at cellular and organ levels are being clarified.
    • Genomics and epigenetics are crucial for diagnosing and understanding dioxin exposure effects.

    Conclusions:

    • Diagnosing dioxin exposure and its long-term effects necessitates advanced techniques.
    • Longitudinal epidemiological studies and improved extrapolation from animal models are vital.
    • Further research integrating genomics and epigenetics is critical for managing dioxin risks.