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Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

Molecular interaction databases.

Sandra Orchard1

  • 1EMBL Outstation - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. orchard@ebi.ac.uk

Proteomics
|May 22, 2012
PubMed
Summary
This summary is machine-generated.

Molecular interaction databases are crucial for cell biology research. Standardized data formats and services like PSICQUIC and IMEx enhance data accessibility and reduce redundancy for researchers.

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Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

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Last Updated: May 22, 2026

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

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09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

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Area of Science:

  • Proteomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Molecular interaction databases are essential for understanding cellular processes.
  • Numerous resources provide this data, increasingly adopting standards from the Human Proteome Organization Proteomics Standards Initiative (HUPO PSI-MI).

Purpose of the Study:

  • To highlight the importance of standardized data formats in molecular interaction databases.
  • To explain how these standards facilitate data sharing and integration through services like PSICQUIC and the IMEx consortium.

Main Methods:

  • Adoption of controlled vocabularies and standardized data formats by molecular interaction databases.
  • Implementation of the PSI Common QUery InterfaCe (PSICQUIC) service.
  • Establishment of the International Molecular Exchange (IMEx) consortium for data curation and integration.

Main Results:

  • Standardized formats enable cross-database queries via PSICQUIC, improving data accessibility.
  • The IMEx consortium consolidates curation efforts, providing non-redundant, consistently annotated interaction data.
  • Cooperation between databases maximizes curation power and user data access.

Conclusions:

  • Standardization and collaborative consortia are transforming molecular interaction data accessibility and usability.
  • These initiatives are vital for advancing the understanding of cell biology through integrated omics data.