TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction
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Updated: May 22, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
Shengchun Dang1, Yao Shen, Kai Yin
1Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Abstract:
Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP. Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD. In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP. Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP. TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier.
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