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Updated: May 22, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Chronic gastritis in dermatitis herpetiformis: a controlled study
Anna Alakoski1, Teea T Salmi, Kaisa Hervonen
1Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland.
Clinical & Developmental Immunology
|May 22, 2012
Summary
Chronic atrophic gastritis is common in the stomach corpus of dermatitis herpetiformis (DH) patients, unlike controls. This finding suggests an autoimmune link and a potential increased risk for gastric cancer in DH.
Area of Science:
- Gastroenterology
- Dermatology
- Oncology
Background:
- Dermatitis herpetiformis (DH) is an autoimmune blistering skin condition.
- Previous research indicates a potential link between DH and chronic atrophic gastritis.
Purpose of the Study:
- To investigate the prevalence and location of chronic gastritis in untreated DH patients compared to dyspeptic controls.
- To assess the association of Helicobacter pylori and intestinal metaplasia with gastritis in DH.
Main Methods:
- Gastric biopsies from the corpus and antrum were analyzed for atrophy and intestinal metaplasia.
- Helicobacter pylori status and duodenal biopsies were also examined.
- 93 untreated DH patients and 186 dyspeptic controls were included.
Main Results:
- Atrophic gastritis was significantly more frequent in the gastric corpus of DH patients (16.0%) than controls (2.7%).
- Antral atrophy was rare in both groups.
- Helicobacter pylori and intestinal metaplasia were more prevalent in DH patients.
- Small-bowel villous atrophy was observed in 76% of DH patients.
Conclusions:
- Chronic atrophic gastritis is common in the gastric corpus of DH patients, suggesting a possible autoimmune etiology beyond H. pylori infection.
- Atrophic gastritis may elevate the risk of gastric cancer in DH patients.
- Upper endoscopy with adequate biopsies is recommended for DH patients.
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