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Published on: March 8, 2012
Distribution of human papillomavirus types in Turkish women
Z S Tuncer1, G Boyraz, N Sahin
1Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey. zstuncer@hacettepe.edu.tr
Purpose Of Investigation:
Since oncogenic types of human papillomavirus (HPV) are associated with a higher risk of cervical cancer and certain types can be controlled by a vaccine, a study has been performed to determine the HPV genotype distribution among Turkish women.
Methods:
The study included patients with abnormal cytology or in the follow-up for cervical intraepithelial neoplasia between 2002 and 2009 at Hacettepe University Hospital. The results of 1797 consecutive cervical samples were analyzed retrospectively. INNO-LiPA HPV genotyping, HPV-Typing and Seeplex HPV 18-plex genotyping tests were used to determine the types of HPV.
Results:
HPV was detected in 404 (22.4%) of 1797 samples studied. HPV DNA was identified in 194 cases by using HPV-Typing test but the specific genotype was not available. The most frequent genotype was HPV 16 which was observed in 103 cases (49.0%).
Conclusion:
HPV 16 was the most common genotype observed among Turkish women with abnormal cytology. It suggests that HPV vaccination may be useful for prevention of cervical cancer in this population.
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