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Updated: May 22, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens

Published on: December 9, 2022

Pseudomyxoma peritonei--case report.

O Nikolic¹, S Djurdjevic, S Stojanovic

¹Department of Radiology, Clinical Center of Vojvodina, Serbia. nikolic.olivera@gmail.com

European Journal of Gynaecological Oncology

|May 23, 2012

Summary

This summary is machine-generated.

Pseudomyxoma peritonei is a rare condition. This case highlights that maximal surgical tumor reduction, even without intra-abdominal chemotherapy or second-look surgery, can lead to long-term survival in select pseudomyxoma peritonei patients.

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Area of Science:

Oncology
Surgical Oncology
Gastroenterology

Background:

Pseudomyxoma peritonei (PMP) is a rare malignancy characterized by mucinous ascites and tumor implants throughout the peritoneal cavity.
The primary tumor often originates from the appendix, leading to widespread abdominal dissemination.
Optimal treatment strategies for PMP remain under investigation, balancing cytoreduction with patient factors.

Observation:

A 58-year-old woman presented with PMP originating from a primary appendiceal tumor.
Maximal surgical tumor reduction was performed, leaving residual implants on the diaphragmatic domes and liver due to technical limitations for extended surgery.
The patient received parenteral chemotherapy but declined second-look surgery and intraperitoneal chemotherapy.

Findings:

Despite incomplete cytoreduction and non-standard adjuvant therapy, the patient achieved a two-year survival.
The patient remained alive with no major complaints, suggesting potential for favorable outcomes with maximal debulking alone in select PMP cases.
This case challenges the necessity of aggressive multimodal therapy in all PMP patients.

Implications:

Maximal surgical debulking may be a critical factor in achieving long-term survival for pseudomyxoma peritonei patients.
Individualized treatment approaches considering surgical feasibility and patient tolerance are essential in managing PMP.
Further research is warranted to identify predictors of response to maximal surgical reduction in PMP.