Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast
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Updated: May 22, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
Yuting Lin1, Tiffany C Kwong, Linden Bolisay
1University of California, Department of Radiological Sciences, Tu and Yuen Center for Functional Onco-Imaging, Irvine, CA 92697, USA. yutingl@uci.edu
Abstract:
It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography system that could acquire images at high intensity-focused ultrasound resolution with use of these nanocapsules. The system is experimentally verified with a phantom study, where a 3-mm fluorescence object embedded 2 cm deep in a turbid medium is successfully recovered based on both intensity and lifetime contrast.
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