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Updated: Aug 12, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
[Neurological symptoms and etiology of severely retarded children]
1Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo.
Insights
Severe intellectual disability in children aged 6-14 is often linked to congenital causes. A significant portion of these cases stem from preventable conditions like perinatal anoxia and meningitis.
Area of Science:
- Pediatrics
- Neurology
- Public Health
Background:
- Intellectual disability (ID) is a complex developmental condition affecting cognitive and adaptive functioning.
- Cerebral palsy, a common co-occurring condition, presents with motor impairments.
- Understanding the etiological factors and timing of onset is crucial for intervention.
Purpose of the Study:
- To investigate the causes and types of severe intellectual disability in children within a specific community.
- To analyze the distribution of etiological factors (congenital, perinatal, postnatal).
- To compare current findings with previous epidemiological reports on intellectual disability.
Main Methods:
- A cross-sectional study identifying 43 patients aged 6-14 with severe intellectual disability.
- Clinical assessment of motor function, categorizing types of cerebral palsy (spastic tetraplegia, diplegia, dyskinetic).
- Retrospective analysis of etiological factors based on patient history and medical records.
Main Results:
- Spastic tetraplegia was the most prevalent motor impairment (23/43 patients).
- Congenital causes accounted for the majority of cases (25/43), followed by postnatal (12/43) and perinatal (6/43) factors.
- A shift towards congenital causes and away from perinatal causes was observed compared to prior studies.
Conclusions:
- Congenital factors are increasingly dominant in severe intellectual disability.
- A substantial proportion of cases are linked to preventable conditions, highlighting the need for improved prenatal and perinatal care.
- Public health initiatives targeting preventable causes like anoxia, meningitis, and vitamin K deficiency are essential.
Abstract:
I identified forty-three patients with severe retardation aged 6-14 years in a defined community. More than half of the patients (23/43) had spastic tetraplegia and 9 had spastic diplegia. Only one case showed abnormal increase of muscle tone of dyskinetic type. The period when they had got underlying causes of their handicaps was as follows : congenital (acquired intrauterine, including intractable cases) 25, perinatal 6, and after the neonatal period 12. An increased proportion of congenital cases and a decreased proportion of perinatal cases are noted when the data were compared with previous reports. About a half of the total cases could be considered to be caused by preventable diseases such as perinatal anoxia, purulent meningitis, or intracranial hemorrhage due to vitamin K deficiency.
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