Related Experiment Video
Updated: May 22, 2026

Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
Asymmetric crying face in a newborn with isotretinoin embryopathy
Dilek Sarici1, Mustafa Ali Akin, Selim Kurtoglu
1Division of Neonatology, Faculty of Medicine, Erciyes University, KayseriDivision of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Erciyes University, KayseriDepartment of Medical Genetics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Abstract:
We report a newborn with asymmetric crying face and other anomalies whose mother had taken isotretinoin during the first month of pregnancy. We hypothesize that asymmetric crying face is a finding of retinoic acid embryopathy and results from the intrauterine effects of retinoic acid on the development of the depressor anguli oris muscle or the mandibular branch of the facial nerve.

