Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function
Edward A Hall1, Erkin Kuru, Michael S VanNieuwenhze
1Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
Organic Letters
|May 23, 2012
Abstract:
The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product.
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