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Updated: May 22, 2026
10:17
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis
John Janiszewski1, Richard Schneider, Brendon Kapinos
1Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA. john.s.janiszewski@pfizer.com
Bioanalysis
|May 23, 2012
Summary
The Apricot Designs Dual Arm (ADDA) instrument enhances bioanalysis throughput in drug discovery. This LC-MS/MS system offers high-speed screening and flexible LC approaches for efficient sample triage.
Area of Science:
- Analytical Chemistry
- Pharmacology
- Biotechnology
Background:
- Drug discovery involves a high volume of diverse samples requiring bioanalysis.
- Limited method development time necessitates rapid sample analysis options.
- Efficient sample triage is crucial for accelerating drug discovery pipelines.
Purpose of the Study:
- To introduce the Apricot Designs Dual Arm (ADDA) instrument, a novel sample delivery system.
- To demonstrate the ADDA instrument's capability for high-throughput bioanalysis.
- To showcase the integration of the ADDA system with existing software and databases.
Main Methods:
- The ADDA instrument utilizes a flexible hardware design and software automation for LC-MS/MS bioanalysis.
- It supports high-throughput LC-MS/MS at speeds of 8-10 seconds per sample.
- The system is capable of multiplexed LC for gradient or isocratic analyses.
Main Results:
- The ADDA instrument significantly enhances throughput for LC-MS/MS bioanalysis in drug discovery.
- It enables rapid screening and in vitro bioanalysis.
- The system integrates seamlessly with DiscoveryQuant™ software and a global MS/MS conditions database.
Conclusions:
- The development of the ADDA sample delivery platform offers a solution for high-throughput bioanalysis.
- Its application in both high-throughput and gradient LC workflows is described.
- The ADDA instrument facilitates efficient sample triage, supporting accelerated drug discovery.
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