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Aerosol delivery during high frequency jet ventilation: an MRI evaluation
Beena G Sood1, Zahid Latif, Yimin Shen
1Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI 48201, USA. bsood@med.wayne.edu
Respiratory Care
|May 23, 2012
Summary
This study shows effective aerosol delivery in neonatal high-frequency jet ventilation (HFJV) circuits, comparing it with conventional mechanical ventilation and high-frequency oscillatory ventilation (HFOV). Conventional ventilation provided the highest aerosol deposition, while HFJV showed promising results.
Area of Science:
- Neonatal respiratory support
- Pulmonary drug delivery
- Medical device engineering
Background:
- Previous studies confirmed aerosol delivery during conventional and high-frequency oscillatory ventilation (HFOV) in piglets using MRI.
- No prior reports exist on aerosol delivery during high-frequency jet ventilation (HFJV).
Purpose of the Study:
- To compare aerosolized gadopentetate dimeglumine (Gd-DTPA) delivery across three neonatal ventilator circuits: conventional mechanical ventilation, HFOV, and HFJV.
Main Methods:
- Aerosols of Gd-DTPA were delivered into an in vitro lung model using a jet nebulizer in the inspiratory limb of each ventilator circuit.
- Magnetic resonance imaging (MRI) was used to visualize and quantify Gd-DTPA deposition at 10 and 20 minutes.
- Gd-DTPA concentration was calculated from signal intensity changes to estimate total deposition.
Main Results:
- Gd-DTPA was successfully visualized in the lung model for all three ventilation types.
- Conventional mechanical ventilation demonstrated the highest Gd-DTPA delivery (2.89 μmol at 20 min).
- High-frequency jet ventilation (HFJV) showed higher delivery (1.98 μmol at 20 min) than HFOV (1.00 μmol at 20 min).
Conclusions:
- This study reports the first successful aerosol delivery within a neonatal HFJV circuit.
- Further research is required for precise quantification of aerosol deposition in HFJV.
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