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Variations in gastrointestinal melanoma metastases
1Department of Radiology, University of Zagreb, Yugoslavia.
Abstract:
In 10 patients with gastrointestinal metastases from cutaneous malignant melanoma, metastases to the stomach were found in 2, the small bowel in 9, and the large bowel in 3. Gastric metastases typically appeared as target lesions. However, the morphology of secondary melanoma deposits to the small and large intestine varied significantly, target lesions being only one possible manifestation. Less common appearances of gut metastases were found in 4 patients. One presented atypically with matted loops of distal ileum resulting in prolonged stasis of barium in the affected areas. In 3 patients, infiltrative and stenotic lesions were found in the distal ileum, terminal ileum and cecum. One stenotic lesion of the distal ileum was accompanied by multiple small polypoid lesions more proximally, and the cecal lesion was ulcerated. Six of the patients presented with polypoid and, occasionally, ulcerated and multiple secondary melanoma deposits. Possible causes for variations in morphology are discussed.
Insights
Cutaneous malignant melanoma can metastasize to the gastrointestinal tract, affecting the stomach, small intestine, and large intestine. The appearance of these secondary melanoma deposits varies, with target lesions being common in the stomach but less so in the intestines.
Area of Science:
- Gastroenterology
- Oncology
- Radiology
Background:
- Cutaneous malignant melanoma is a significant health concern.
- Gastrointestinal metastases from melanoma can present diagnostic challenges.
Purpose of the Study:
- To describe the diverse morphological appearances of gastrointestinal metastases from cutaneous malignant melanoma.
- To analyze the varied presentations of secondary melanoma in the stomach, small intestine, and large intestine.
Main Methods:
- Retrospective analysis of 10 patients with gastrointestinal metastases from cutaneous malignant melanoma.
- Review of imaging findings, focusing on the morphology of metastases in different parts of the gastrointestinal tract.
Main Results:
- Metastases were observed in the stomach (2/10), small bowel (9/10), and large bowel (3/10).
- Gastric metastases commonly appeared as target lesions.
- Intestinal metastases exhibited varied morphologies, including target lesions, matted loops, infiltrative/stenotic lesions, and polypoid/ulcerated deposits.
Conclusions:
- Gastrointestinal metastases from cutaneous malignant melanoma demonstrate significant morphological variability.
- Radiologists and clinicians should be aware of these diverse presentations for accurate diagnosis.