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Updated: May 22, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

TP53 codon 72 polymorphism with hepatocellular carcinoma: a metaanalysis.

C Ding¹, H Yu, H Yu

¹The Fourth Department of General Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.

The Journal of International Medical Research

|May 23, 2012

Summary

This summary is machine-generated.

The TP53 codon 72 polymorphism, a variation in the tumor protein p53 gene, may influence hepatocellular carcinoma (HCC) risk. This meta-analysis suggests a decreased cancer risk in certain models, particularly in Asian populations and hospital-based studies.

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Published on: March 21, 2018

Area of Science:

Genetics
Oncology
Molecular Biology

Background:

The TP53 gene is crucial in tumor suppression.
Codon 72 polymorphism (Arg72Pro) is a common genetic variation.
Its association with hepatocellular carcinoma (HCC) risk remains debated.

Purpose of the Study:

To precisely define the relationship between TP53 codon 72 polymorphism and HCC susceptibility.
To conduct a meta-analysis of existing case-control studies.

Main Methods:

Systematic literature search for TP53 codon 72 polymorphism and HCC risk studies.
Meta-analysis of seven case-control studies (1511 cases, 2165 controls).
Calculation of pooled odds ratios using additive, dominant, and recessive models.

Main Results:

A significantly decreased HCC risk was observed in the overall dominant model and in Asian populations.
This protective effect was noted in hospital-based but not population-based studies.
No association was found when stratified by hepatitis B or C virus infection status.

Conclusions:

The TP53 codon 72 polymorphism may play a role in HCC development.
Further research is needed to elucidate its precise function in hepatocarcinogenesis.