Related Experiment Video
Updated: May 22, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Climatic factors correlate with innate immune response in children with Dermatophagoides farinae-induced allergic
1Department of Paediatrics, Chongming Branching Hospital, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 25 Nan men gang Road, Chongming County, Shanghai 202150, China. tanyq66@yahoo.cn
Objective:
To determine the effect of climatic factors on immune markers in children with Dermatophagoides farinae induced asthma.
Methods:
Serum concentrations of macrophage migration inhibitory factor (MIF), eosinophil cationic protein (ECP) and D. farinae-specific immunoglobulin E (DF-sIgE), together with peripheral blood eosinophil counts, were measured in children with D. farinae induced (n = 75) or non-D. farinae-induced asthma (n = 17), and in healthy controls (n = 30). Mean temperature and relative humidity in the month before enrolment were calculated from meteorological data.
Results:
MIF, ECP and eosinophil counts were significantly higher in children with D. farinae-induced asthma than in controls, but comparable with non-D. farinae-induced asthma. Children with D. farinae-induced asthma in a low temperature (< 16 °C) or low relative humidity (< 70%) climate had significantly lower DF-sIgE, MIF, ECP and eosinophil counts than those in a high temperature or high humidity climate. DF-sIgE correlated positively with MIF, ECP and eosinophil count in D. farinae-induced asthma.
Conclusions:
Temperature and humidity influenced MIF, ECP, eosinophil count and DF-sIgE in D. farinae-induced asthma. Understanding this relationship may provide new strategies for asthma prevention and treatment.
Related Concept Videos
Asthma I: Introduction
Asthma-I: Introduction
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations
Allergic Reactions
