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Physiological regulatory networks: ecological roles and evolutionary constraints
Alan A Cohen1, Lynn B Martin, John C Wingfield
1Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, CHUS-Fleurimont, 12ème Ave N, Sherbrooke, QC J1H 5N4, Canada. Alan.Cohen@USherbrooke.ca
Trends in Ecology & Evolution
|May 23, 2012
Summary
Understanding physiological regulatory networks (PRNs) as integrated systems reveals their crucial roles in ecology and evolution. PRN structure influences individual performance and evolutionary trajectories by interconnecting physiological processes.
Area of Science:
- Physiological ecology
- Evolutionary physiology
- Systems biology
Background:
- Traditional research often isolates physiological functions.
- Physiological regulatory networks (PRNs) are complex systems.
- Interactions within PRNs are key to organismal function.
Purpose of the Study:
- To explore the implications of viewing PRNs as integrated wholes.
- To highlight novel roles of PRNs in ecology and evolution.
- To discuss how PRN structure shapes individual performance and evolutionary patterns.
Main Methods:
- Conceptual analysis of physiological regulatory networks.
- Integration of ecological and evolutionary physiology perspectives.
- Systems-level examination of physiological interactions.
Main Results:
- PRNs reveal novel roles for physiology in organismal ecology and evolution.
- Interactions within PRNs constrain or facilitate evolutionary change.
- PRN structure influences homeostasis, fitness, and performance.
- Dietary micronutrients and immune regulation exemplify PRN constraints.
Conclusions:
- Viewing PRNs as integrated systems provides a powerful framework for understanding life.
- PRN structure is a critical determinant of both individual adaptation and macroevolutionary patterns.
- Future research should focus on the system-level properties of PRNs.
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