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Considerations for importing live genetically modified mice from academic laboratories.

Jennifer A Tyson¹

¹Department of Neuroscience, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA. Jat2020@med.cornell.edu

|May 23, 2012

Summary

Sharing genetically modified mice between institutions requires clear communication and preparation. Importing labs must plan for animal health, breeding, and colony management to ensure successful research collaborations.

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Area of Science:

Genetics and Genomics
Animal Models
Laboratory Animal Science

Background:

Genetically modified mice are essential for studying gene function in vivo.
Inter-institutional transfer of these valuable research tools is common.
Established guidelines for this collaborative process are currently lacking.

Purpose of the Study:

To provide recommendations for initiating and managing the exchange of genetically modified mice between research institutions.
To outline best practices for successful inter-laboratory collaboration involving animal resources.

Main Methods:

The study offers practical suggestions based on common challenges in resource sharing.
Emphasis is placed on proactive planning and clear communication between collaborating institutions.

Main Results:

Clear communication of expectations between the donating and importing institutions is crucial.
Proactive preparation by the importing institution regarding animal health, breeding, and colony management is essential.
Prompt verification of animal details (number, sex, age, genotype) upon arrival is recommended.

Conclusions:

Establishing clear guidelines and thorough preparation facilitates the efficient and ethical sharing of genetically modified mice.
Collaborative efforts in sharing animal resources enhance research outcomes and benefit the scientific community.