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Updated: May 22, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
Endogenous thyroid-stimulating hormone and radioactive iodine uptake in normal subjects
Patricio González1, Rodrigo Jaimovich, Verónica Araya
1Sección Medicina Nuclear, Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Santiago, Chile. pgonzalez@redclinicauchile.cl
Abstract:
In 105 normal volunteers, 52 male and 53 female, mean age 45 (range, 20-68), serum thyroid-stimulating hormone (TSH) (1.46 ± 0.7; range, 0.43-3.87 microUI/mL) and 24-hour thyroid radioactive iodine uptake (RAIU) (16.15% ± 4.78% range, 6.45%-30.08%) were measured. Additionally, TSH was 1.18 ± 0.5 microUI/mL for 20 to 29 year-olds and 1.59 ± 0.9 microUI/mL for 60 to 68 year old (P = 0.037). RAIU was 18.30 ± 4.5 for 20 to 29-year-olds and 14.92 ± 3.1 for 60 to 68 year-olds (P = 0.009). TSH trends positively and RAIU at 24 hours correlates negatively with aging of the pituitary axis.
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