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Diffusion tensor imaging shows structural remodeling of stroke mirror region: results from a pilot study
Cristina Granziera1, Hakan Ay, Susan P Koniak
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. cristina.granziera@chuv.ch
European Neurology
|May 23, 2012
Summary
Diffusion tensor imaging (DTI) revealed structural changes in the contralesional hemisphere during stroke recovery. These findings highlight the non-injured brain hemisphere's role in recovery after ischemic stroke.
Area of Science:
- Neuroimaging
- Stroke Recovery Research
- Diffusion Tensor Imaging (DTI)
Background:
- The role of the non-injured hemisphere in stroke recovery remains unclear.
- This study investigates structural changes in the contralesional hemisphere post-stroke.
Purpose of the Study:
- To explore structural changes in the contralesional hemisphere using DTI in well-recovered stroke patients.
- To understand the brain's adaptive mechanisms following ischemic stroke.
Main Methods:
- Analyzed serial DTI data from 16 stroke patients with good functional outcomes.
- Measured apparent diffusion coefficient (ADC) and fractional anisotropy in gray matter (GM) and white matter (WM).
- Examined infarct, contralesional infarct mirror regions, and surrounding areas.
Main Results:
- Increased GM and WM ADC in the infarct and infarct mirror regions (p < 0.01).
- Decreased WM fractional anisotropy in the infarct mirror region (p < 0.05).
- No significant changes observed in other brain regions.
Conclusions:
- DTI metrics detect regional structural changes in the contralesional hemisphere during stroke recovery.
- Further research in larger cohorts is necessary to validate these findings.
