Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Procalcitonin levels as a predictor of antibiotic treatment in pediatric diabetic ketoacidosis.

BMC pediatrics·2026

Same author

Inhaled Technosphere Insulin in Children with Diabetes: The INHALE-1 Extension Study.

Diabetes technology & therapeutics·2026

Same author

High-Resolution Genetic Analysis in Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.

The Journal of clinical endocrinology and metabolism·2025

Same author

Type 2 Diabetes in a Patient With IMAGe Syndrome Secondary to Polymerase Epsilon Pathogenic Variants.

JCEM case reports·2025

Same author

Diabetic Ketoacidosis in a Pediatric Patient with Cystic Fibrosis-related Diabetes.

JCEM case reports·2025

Same author

Implementation of After-Hours Nurse Line in an Academic Pediatric Endocrinology Practice.

Pediatric diabetes·2025

Search research articles

Related Experiment Video

Updated: May 22, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

Transient neonatal hypocalcemia: presentation and outcomes.

Teena C Thomas¹, Joshua M Smith, Perrin C White

¹Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

|May 23, 2012

Summary

Late-onset neonatal hypocalcemia is more common in Hispanic and male infants. This condition, often linked to vitamin D and magnesium deficiencies, is effectively treated with supplements and dietary changes.

More Related Videos

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Related Experiment Videos

Last Updated: May 22, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice

Published on: June 11, 2020

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Biochemical Measurement of Neonatal Hypoxia

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

Area of Science:

Neonatology
Pediatric Endocrinology
Nutritional Science

Background:

Transient neonatal hypocalcemia is a common concern in newborns.
Late-onset hypocalcemia presents after the first week of life, requiring specific diagnostic and management approaches.

Purpose of the Study:

To determine the incidence of moderate-to-severe transient neonatal hypocalcemia in term neonates.
To characterize affected infants and evaluate the outcomes of their management strategies.

Main Methods:

A retrospective review of medical records was conducted for term infants under 31 days of age presenting with hypocalcemia.
Inclusion criteria required ionized calcium levels below 1.00 mmol/L (4.00 mg/dL).

Main Results:

Seventy-eight infants met the criteria, with a median age at admission of 8.0 days.
Most affected infants were male (71.8%) and Hispanic (62.8%), often presenting with severe hypocalcemia, hyperphosphatemia, and hypomagnesemia.
Vitamin D insufficiency/deficiency was noted in all tested infants, and all responded well to supplementation and dietary modifications.

Conclusions:

Moderate-to-severe late-onset neonatal hypocalcemia is more prevalent in Hispanic and male infants.
The condition frequently indicates coexistent vitamin D and hypomagnesemia, which are manageable with prompt therapy.
Neuroimaging evaluations did not alter management decisions for neonates presenting with seizures and hypocalcemia.