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Detection of human bocaviruses 1, 2 and 3 in Irish children presenting with gastroenteritis

O Cashman1, H O'Shea

  • 1Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland.

Archives of Virology
|May 23, 2012
PubMed

Insights

Human bocavirus (HBoV) is a growing cause of gastroenteritis in young children. This study found HBoV types 1, 2, and 3, including new recombinant strains, in Irish children, marking the first detection of all three types in the region.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Public Health

Background:

  • Human bocavirus (HBoV) is increasingly recognized globally as a cause of gastroenteritis, particularly in infants and young children (6-24 months).
  • Previous studies have documented HBoV prevalence in various international settings, but data from Ireland, especially southern Ireland, remained limited.

Purpose of the Study:

  • To investigate the prevalence and types of human bocavirus in non-bacterial gastroenteritis cases in the Munster region of Ireland.
  • To identify specific HBoV genotypes and detect any novel or recombinant strains circulating in the studied population.

Main Methods:

  • Analysis of 155 non-bacterial gastroenteritis samples (rotavirus-, adenovirus-, norovirus-positive) collected from patients in Munster, Ireland (2006-2008).
  • Molecular detection and typing of human bocavirus (HBoV) using established diagnostic techniques.
  • Identification of HBoV genotypes (HBoV1, HBoV2, HBoV3) and characterization of recombinant strains.

Main Results:

  • Human bocavirus (HBoV) was detected in 12 out of 155 (7.7%) gastroenteritis samples.
  • Three distinct HBoV types—HBoV1, HBoV2, and HBoV3—were identified.
  • Four recombinant HBoV strains were also isolated, indicating genetic diversity and recombination events.

Conclusions:

  • This study reports the first detection of human bocavirus types 1, 2, and 3, along with recombinant strains, in southern Ireland.
  • The findings highlight the circulation of diverse HBoV strains in pediatric gastroenteritis cases in the region.
  • Further research is warranted to understand the clinical significance and epidemiological impact of HBoV and its recombinant forms in Ireland.

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