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Published on: September 4, 2013
Transient focal cerebral ischemia upregulates immunoproteasomal subunits
1Division of Basic Biological Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Abstract:
This study was designed to determine whether focal cerebral ischemia alters the expression of the immunoproteasomal (i-proteasomal) subunits. Transient cerebral ischemia significantly increased the expression of the i-proteasomal subunits, 20S β1i (LMP2) and β5i (LMP7) in the parietal cortex and hippocampus. This alteration was associated with a remarkable increase in ubiquitinated proteins. It is likely that the postischemic induction of the i-proteasome plays an important role in coping with the damaged proteins and thus may have an important effect on neuronal survival and death.
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