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Related Experiment Video

Updated: May 22, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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Published on: September 10, 2018

Association between calcifying nanoparticles and placental calcification.

Yanan Guo¹, Dechun Zhang, He Lu

¹Molecular Medicine and Tumor Research Center, Chongqing Medical University, Yuzhong District, Chongqing, People's Republic of China.

International Journal of Nanomedicine

|May 23, 2012

Summary

Novel calcifying nanoparticles were identified in placental calcification cases. These nanobacteria-like particles, observed in placental tissues, suggest a potential role in the pathogenesis of placental calcification.

Keywords:

16S rRNA gene calcifying nanoparticles nanobacteria placental calcification

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Published on: June 18, 2013

Area of Science:

Obstetrics and Gynecology
Microbiology
Pathology

Background:

Placental calcification is a condition affecting pregnancy.
The role of microorganisms in placental calcification is not fully understood.

Purpose of the Study:

To investigate the potential involvement of calcifying nanoparticles in placental calcification.
To characterize novel nanoparticles found in calcified placental tissues.

Main Methods:

Collected placental tissues from calcification cases and controls.
Cultured nanoparticles from tissues using specialized methods.
Examined nanoparticles via transmission electron microscopy (TEM) and monitored growth via optical density (OD).
Sequenced 16S rRNA genes of cultured nanoparticles.

Main Results:

Identified novel calcifying nanoparticles (50-500 nm) with electron-dense shells in calcified placental tissues.
Observed nanoparticle growth in culture from calcified tissues, but not controls.
16S rRNA gene sequencing indicated these nanoparticles are novel nanobacteria.

Conclusions:

The study identified novel nanobacteria-like calcifying nanoparticles in placental calcification.
These findings suggest a potential contribution of these nanoparticles to the pathogenesis of placental calcification.