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Related Experiment Video

Updated: May 22, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Core shell methyl methacrylate chitosan nanoparticles: In vitro mucoadhesion and complement activation.

F Talaei1, M Azhdarzadeh, H Hashemi Nasel

  • 1Nanotechnology Research center, Faculty of Pharmacy.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|May 23, 2012
PubMed
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Thiolated chitosan nanoparticles enhance mucoadhesion and complement activation for improved mucosal delivery of peptides and proteins. This modified chitosan offers superior mucoadhesive and permeation-enhancing properties compared to unmodified chitosan.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Chitosan nanoparticles enhance mucoadhesion and permeation of large molecules across mucosal surfaces.
  • Thiolated chitosan offers potential for improved functionality in drug delivery systems.

Purpose of the Study:

  • To develop polysaccharide-coated nanoparticles using thiolated chitosan.
  • To confer specific functionalities, including enhanced mucoadhesion and permeation, to nanoparticles.

Main Methods:

  • Methyl methacrylate nanoparticles were coated with thiolated chitosan via radical polymerization.
  • Thiolation was achieved using glutathione (GSH).
  • Mucoadhesion was assessed by mucin adsorption; complement activation was measured via hemolytic capacity in human serum.
Keywords:
Complement consumptionGlutathioneMucosal drug deliveryNanoparticlesThiolated chitosan

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Last Updated: May 22, 2026

Preparation and Characterization of SDF-1&#945;-Chitosan-Dextran Sulfate Nanoparticles
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Main Results:

  • Successful synthesis and conjugation of thiolated chitosan to methyl methacrylate (MMA) homopolymer confirmed by FT-IR and (1)HNMR.
  • Spherical nanoparticles (334-650 nm) with positive zeta potential indicated surface cationic polysaccharide.
  • Increased thiolated chitosan enhanced mucoadhesion and complement activation, though not dose-dependently.

Conclusions:

  • Nanoparticles developed with thiolated chitosan are suitable for mucosal delivery of peptides and proteins.
  • Thiolated chitosan demonstrated superior mucoadhesion and complement activation compared to unmodified chitosan.