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Renoprotective effects of combining ACE inhibitors and statins in experimental diabetic rats

M Mudagal1, J Patel, Nc Nagalakshmi

  • 1Department of Pharmacology, Acharya and B M Reddy College of Pharmacy, Soladevanahalli Village, Heseraghatta Road, Chikkabanawar Post, Bangalore-560090, India.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|May 23, 2012
PubMed
Abstract

Insights

The combination of telmisartan and atorvastatin significantly improved kidney function in diabetic rats, reducing markers of kidney damage. This combination therapy offers better renoprotection than individual drugs for diabetic nephropathy.

Area of Science:

  • Nephrology
  • Pharmacology
  • Endocrinology

Background:

  • Diabetic nephropathy is a major complication of diabetes mellitus.
  • Angiotensin II receptor antagonists and HMG CoA reductase inhibitors show renoprotective potential.
  • Combination therapy may offer enhanced benefits for diabetic kidney disease.

Purpose of the Study:

  • To evaluate the renoprotective effects of telmisartan and atorvastatin combination therapy.
  • To compare the efficacy of combination therapy versus monotherapy in a rat model of diabetic nephropathy.

Main Methods:

  • Diabetes was induced in rats using Streptozotocin (STZ).
  • Rats received telmisartan and atorvastatin as monotherapy or combination therapy for 30 days.
  • Renal function and kidney histology were assessed.

Main Results:

  • Combination therapy significantly improved urine glucose, serum cholesterol, creatinine, blood urea nitrogen, total protein, albumin, and microalbuminuria.
  • Kidney pathological injury was attenuated by the combination therapy.
  • No significant changes were observed in serum glucose and triglyceride levels with combination therapy.

Conclusions:

  • Telmisartan and atorvastatin combination therapy demonstrates superior renoprotective effects compared to monotherapy in STZ-induced diabetic nephropathy.
  • The combination therapy attenuated diabetic nephropathy progression by reducing proteinuria and microalbuminuria.
  • Histopathological analysis confirmed the renoprotective benefits of the combination therapy.
Keywords:
AtorvastatinDiabetic nephropathyTelmisartan

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