Related Experiment Video
Updated: May 22, 2026
09:20
The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
Published on: October 31, 2016
Endothelium under stress: local and systemic messages
Sergey V Brodsky1, Michael S Goligorsky
1Department of Pathology, The Ohio State University, Columbus, OH, USA.
Seminars in Nephrology
|May 24, 2012
Summary
Endothelial cells respond to stress via hormesis, with intensity determining outcomes from regeneration to death. Kidney injury triggers inflammation and adaptive stress responses in these cells.
Area of Science:
- Cellular biology
- Physiology
Background:
- Endothelial cells exhibit hormesis, a dose-dependent response to stressors.
- Stress intensity dictates cellular outcomes, ranging from pro-regenerative to pro-lethal effects.
Purpose of the Study:
- To explore endothelial cell responses to acute kidney injury (AKI).
- To understand the dual nature of cellular defense and damage signaling in AKI.
Main Methods:
- Review of stress-induced hormesis principles.
- Analysis of endothelial responses in AKI models.
Main Results:
- AKI induces a proinflammatory endothelial phenotype with increased adhesion molecules and oxidative stress.
- Simultaneously, adaptive, pro-survival mechanisms are activated.
- Endothelial cells release systemic distress signals influencing homeostasis or injury progression.
Conclusions:
- Kidney endothelial cells display hormetic responses to AKI, balancing damage and defense.
- These responses involve complex signaling pathways with potential for both repair and exacerbation of injury.
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