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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
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Endothelial cells and thrombotic microangiopathy

David Motto1

  • 1Department of Internal Medicine and Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. david-motto@uiowa.edu

Seminars in Nephrology
|May 24, 2012
PubMed

Thrombotic microangiopathy represents the clinical picture of thrombocytopenia and hemolytic anemia in the setting of small blood vessel thrombosis, accompanied by varying degrees of organ dysfunction. Well known to both nephrologists and hematologists alike, among the most common and best-studied thrombotic microangiopathy are hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura. Despite sharing a strong clinical and historical relationship, these disorders represent distinct clinical and pathophysiological entities. This article reviews recent progress into the pathogenesis of thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, focusing on events taking place at the endothelial surface.

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