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The relationship between intracranial arterial stenosis and glomerular filtration rate

Kyusik Kang1, Young-Hwan Hwang

  • 1Department of Neurology, Eulji General Hospital, Eulji University, 280-1 Hagye 1-dong, Nowon-gu, Seoul, Republic of Korea. cobnut1@snu.ac.kr

Journal of Thrombosis and Thrombolysis
|May 24, 2012
PubMed

Insights

Poor kidney function is linked to intracranial arterial stenosis (IAS) in adults. Lower estimated glomerular filtration rate (eGFR) indicates higher IAS prevalence and severity, highlighting a connection between kidney health and brain arteries.

Area of Science:

  • Nephrology
  • Neurology
  • Cardiovascular Medicine

Background:

  • Poor renal function is a known risk factor for cardiovascular diseases, including large-vessel issues like arterial calcification and heart failure.
  • Intracranial arterial stenosis (IAS) is a significant cause of stroke, and its association with renal function requires further investigation.

Purpose of the Study:

  • To investigate the relationship between renal function and the presence and severity of intracranial arterial stenosis (IAS) in a stroke-free adult population.
  • To determine if markers of kidney function correlate with the degree of narrowing or occlusion in major brain arteries.

Main Methods:

  • Analysis of data from 283 Korean adults (age ≥45) without a history of stroke who underwent brain 3D time-of-flight magnetic resonance angiography.
  • Intracranial arterial stenosis (IAS) was defined as ≥25% luminal diameter narrowing or occlusion in the basilar or middle cerebral arteries.
  • Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation.

Main Results:

  • Intracranial arterial stenosis (IAS) was present in 59% of the study participants.
  • Higher serum creatinine levels (indicating poorer renal function) were associated with an increased prevalence of IAS.
  • Higher estimated glomerular filtration rates (eGFR) were linked to a decreased prevalence of IAS, with a significant inverse relationship observed between eGFR and IAS severity.

Conclusions:

  • Poor renal function, indicated by lower eGFR, is significantly associated with the presence of intracranial arterial stenosis (IAS) in stroke-free Korean adults.
  • The degree of renal impairment correlates with the severity of intracranial arterial stenosis (IAS), suggesting a shared pathophysiology.
  • These findings underscore the importance of assessing renal function in individuals with or at risk for intracranial arterial stenosis (IAS).

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