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Updated: May 22, 2026
Human Blastocyst Biopsy and Vitrification
Published on: July 26, 2019
Supernumerary blastocyst cryopreservation: a key prognostic indicator for patients opting for an elective single
Christine Mullin1, Alan S Berkeley, Jamie A Grifo
1NYU Fertility Center, New York University, Langone Medical Center, New York, NY 10016, USA. christine.mullin@gmail.com
Objective:
To determine if patients, less than 40 years of age with or without day 5 cryopreservation (d5 cryo), compromise their pregnancy rate (PR) by choosing an eSBT.
Design:
Retrospective analysis
Setting:
University IVF center
Patients:
2,203 non-donor fresh IVF cycles in women <40 years of age from January 2004 to January 2010.
Interventions:
None
Main Outcome Measure(S):
Eggs retrieved, Embryos cryopreserved, Implantation Rates, Clinical Pregnancy Rates, Live Birth Rates, Spontaneous Abortion Rates
Results:
Pregnancy outcomes in women <40 years with or without d5 cryo were compared according to whether patients underwent an eSBT versus a 2BT in non-donor fresh IVF cycles. Overall, eSBT was associated with elimination of twinning while maintaining a high clinical pregnancy rate in both groups with d5 cryo (75 % eSBT versus 72 % 2BT) and groups without d5 cryo (48 % eSBT versus 56 % 2BT).
Conclusions:
In this study, patients <40 years of age have eliminated twinning by electively choosing to transfer a single blastocyst without compromising their PR if embryos are available for d5 cryo, and suffer only a non-statistically significant drop in their PR if there are no embryos available for d5 cryo in exchange for the benefit of eliminating the obstetrical risk of twinning.
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