Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial.

Anaesthesia·2024

Same author

Impact of the Covid-19 pandemic on the performance of machine learning algorithms for predicting perioperative mortality.

BMC medical informatics and decision making·2023

Same author

Sex-specific issues of central and peripheral arginine-vasopressin concentrations in neurocritical care patients.

BMC neuroscience·2022

Same author

[Potential effect of the stimulus threshold level of the nociceptive flexion reflex (NFRT) on mortality and delirium incidence in the critically ill patient: a retrospective cohort analysis].

Die Anaesthesiologie·2022

Same author

[Managing the pandemic-relocation concept for COVID-19 intensive care patients and non-COVID-19 intensive care patients in Baden-Württemberg].

Der Anaesthesist·2021

Same author

[Machine learning in anesthesiology].

Der Anaesthesist·2020

Search research articles

Related Experiment Video

Updated: May 22, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

[Postoperative cognitive dysfunction. Possible neuronal mechanisms and practical consequences for clinical routine].

R Haseneder¹, E Kochs, B Jungwirth

¹Klinik für Anaesthesiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675 München, Deutschland. r.haseneder@lrz.tum.de

Der Anaesthesist

|May 24, 2012

Summary

Postoperative cognitive dysfunction (POCD) is a decline in memory and thinking skills after surgery, mainly in older adults. Its causes are complex and not fully understood, but maintaining patient stability during surgery is key.

More Related Videos

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Related Experiment Videos

Last Updated: May 22, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Published on: December 29, 2016

Area of Science:

Neuroscience
Geriatric Medicine
Anesthesiology

Context:

Postoperative cognitive dysfunction (POCD) affects elderly patients after surgery, leading to prolonged cognitive decline.
The exact mechanisms underlying POCD remain elusive, suggesting multifactorial causes.
Current research explores the neurotoxic effects of anesthetics and surgery-induced neuroinflammation as potential contributors to POCD.

Purpose:

To review the current understanding of the causes and potential mechanisms of postoperative cognitive dysfunction (POCD).
To highlight the importance of perioperative physiological homeostasis in preventing POCD.
To assess the current clinical evidence regarding anesthesiological procedures and their impact on POCD.

Summary:

POCD is characterized by a lasting decrease in cognitive functions, particularly in elderly individuals post-surgery.
Potential causes include anesthetic neurotoxicity affecting learning and memory, and neuroinflammation triggered by surgical stress.
Maintaining perioperative physiological stability is considered the most critical preventive strategy for POCD.

Impact:

This review underscores the need for further research into the multifactorial causes of POCD.
It emphasizes the critical role of anesthetic management and perioperative care in mitigating cognitive risks for surgical patients.
The findings highlight the current limitations in providing definitive recommendations on specific anesthesiological techniques to prevent POCD.