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Updated: Dec 30, 2025

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

Published on: March 12, 2015

Foodborne toxoplasmosis.

Jeffrey L Jones¹, J P Dubey

¹Parasitic Diseases Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. jlj1@cdc.gov

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|May 24, 2012

Summary

Toxoplasmosis, a significant foodborne illness, is transmitted through undercooked meats and contaminated produce. Prevention involves safe food handling, proper cooking, and reducing environmental parasite spread.

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Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

Published on: November 3, 2009

Area of Science:

Food Safety
Parasitology
Public Health

Background:

Toxoplasmosis is a major cause of foodborne illness, hospitalizations, and deaths.
Transmission occurs via consumption of undercooked meats (pork, lamb, wild game) and contaminated fruits/vegetables from soil with cat feces.
Emerging trends like free-range meat production may elevate risks of Toxoplasma gondii contamination.

Purpose of the Study:

To summarize the transmission routes and prevention strategies for foodborne toxoplasmosis.

Main Methods:

Review of existing literature on Toxoplasma gondii transmission pathways.
Analysis of food production and handling practices contributing to human infection.
Identification of key control measures for reducing foodborne toxoplasmosis.

Main Results:

Major sources include undercooked meats and produce contaminated by cat feces.
Free-range meat production presents a potential increased risk for Toxoplasma gondii.
Effective prevention relies on safe food practices and environmental controls.

Conclusions:

Foodborne toxoplasmosis is a significant public health concern.
Implementing safe meat production, thorough cooking, and proper produce washing are crucial for prevention.
Reducing environmental oocyst contamination is vital to limit human exposure.