Related Experiment Video
Updated: May 22, 2026
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
[Screening for colorectal cancer. Current evidence and novel developments]
1Medizinische Klinik und Poliklinik II, Klinikum der Ludwig-Maximilians-Universität München, Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland. frank.kolligs@med.uni-muenchen.de
Der Radiologe
|May 24, 2012
Summary
Colorectal cancer screening effectively reduces incidence and mortality. Colonoscopy is preferred, but newer methods like fecal immunochemical tests and molecular tests show promise for future colorectal cancer detection.
Area of Science:
- Oncology
- Gastroenterology
- Medical Diagnostics
Context:
- Colorectal cancer (CRC) is a significant cause of cancer morbidity and mortality.
- Screening is proven to decrease CRC incidence and mortality.
- Risk stratification includes normal, increased family risk, and hereditary syndromes.
Purpose:
- To review standard and emerging screening methods for colorectal cancer.
- To compare the efficacy and sensitivity of various colorectal cancer screening modalities.
- To provide practical recommendations for colorectal cancer screening based on current evidence.
Summary:
- Guaiac-based fecal occult blood testing has the highest evidence among older methods.
- Fecal immunochemical tests offer higher sensitivity than guaiac-based tests.
- Colonoscopy is the reference standard; CT colonography and capsule endoscopy show high sensitivity for neoplasia.
- Emerging molecular tests detecting DNA changes in stool or blood hold potential to replace current occult blood tests.
Impact:
- Colonoscopy remains the primary tool for colorectal neoplasia screening.
- Fecal occult blood testing is recommended only if colonoscopy is refused.
- Advanced techniques like CT colonography and molecular tests are poised to enhance future colorectal cancer screening programs.
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