Survival rate of recurrent cervical carcinoma

To determine the survival rate of recurrent cervical carcinoma and clinical variables influencing survival.

Eighty eligible patients with recurrent cervical carcinoma were identified from the tumor registry record of gynecologic oncology division, Rajavithi Hospital between January 2004-December 2010. The pathological and clinical data were retrospective reviewed. Numerous clinical variables were analyzed including age, histopathology, primary staging, site of recurrence, complete treatment time to recurrence and initial treatment after recurrence.

Among the 80 patients, mean age of the patients were 48.11 years (SD = 9.62). Median time from complete primary treatment to recurrence was 11.7 months. Fifty four cases (67.5%) were squamous cell carcinoma and the others were nonsquamous cell carcinoma. Seventy two cases (90.1%) were previously treated with radiation therapy. Sixty six cases (82.5%) had only pelvic recurrence without distant disease. Median follow-up period of the present study was 14.2 months. Two-year survival rate of the group was 33.7%, median survival was 15.4 months. Two years survival rate of the patients received surgery, radiation, chemotherapy and supportive only as initial treatment after recurrence were 43.6%, 53.3%, 18.1% and 25.0%, respectively. Whereas median survival of the patients received surgery, radiation, chemotherapy and supportive only as initial treatment after recurrence were 20.7, 24.5, 11.4 and 10.8 months respectively. Site of recurrent and type of initial treatment modality after recurrence had statistic significance in multivariable analysis (p = 0.001 and p = 0.026, respectively).

Survival rate of recurrent cervical carcinoma was poor Surgery and radiation as initial treatment modality after recurrence may have survival benefit in well selected patients.